Physiological Causes of Decreased WBCs

Physiological reductions in WBCs are less common and typically involve natural fluctuations rather than pathological processes: Circadian rhythm: Lower counts in the early morning or during rest Individual variability: Normal baseline variations among healthy individuals Adaptive responses: Brief dips after mild stressors resolve (e.g., short-term fasting) Unlike pathological causes (e.g., infections or bone marrow disorders), physiological decreases are mild, transient, and rarely require intervention. However, persistent or significant drops warrant medical evaluation to exclude underlying conditions.